Julie Leegwater-Kim, MD, PhD; Neurology
Low-frequency Repetitive Transcranial Magnetic Stimulation in Patients with Medication-refractory Tardive Dyskinesia (TD).
This Lahey physician-initiated pilot study is funded by a Wise grant. The primary objective of this study is to determine the safety and effectiveness of repetitive transcranial magnetic stimulation to treat patients with Tardive Dyskinesia (TD). Currently there is no standard treatment or cure for this condition. Transcranial magnetic stimulation, or TMS, is an experimental, non-invasive, neurophysiologic procedure that stimulates current in the brain using a magnetic field to pass the scalp and the skull safely and to painlessly stimulate and alter brain activity.
Christopher Tretter, MD; Oncology
Neoadjuvant Chemotherapy Plus Nephroureterectomy for Locally Advanced Upper Tract Transitional Cell Cancer
This non-randomized study aims to determine the effectiveness of neoadjuvant chemotherapy (chemotherapy given prior to surgery) in patients with transitional cell carcinoma (TCC) of the upper tract (kidney or ureter) followed by surgery. The treated group of patients will be compared to Lahey patients from past years who underwent surgery alone to treat their disease.
Prior research has demonstrated that neoadjuvant chemotherapy using the agents gemcitabine and cisplatin has an overall survival advantage in treating patients with locally advanced TCC of the bladder. However, the chemotherapy drugs being used in the current study, gemcitabine and cisplatin, have not yet been tested as neoadjuvant treatment for upper tract TCC.
Sergio Waxman, MD; Cardiology
Intensive: A Multi-Center, Phase IIIb, Stratified, Randomized, Open-Label Trial to Evaluate Intensive Apidra/Lantus Therapy vs. Sliding Scale Insulin on Infarct Size in Hyperglycemic Subjects with Anterior STEMI (ST Elevation Myocardial Infarction) Undergoing Percutaneous Coronary Intervention
A study comparing the effectiveness of standard sliding scale insulin with a new type of insulin/potassium IV drip in patients with hyperglycemia and myocardial infarct. Despite advances in managing patients with acute myocardial infarction (MI), diabetic MI patients continue to experience high morbidity and mortality. This trial is part of the first large scale multicenter clinical study to determine whether tight control of blood sugar with intensive insulin treatment reduces the size of the myocardial infarct compared with standard blood sugar treatment in diabetic patients with AMI.
